NOC:Computational Systems Biology


Lecture 1 - Introduction


Lecture 2 - Introduction to Modelling


Lecture 3 - Introduction to Modelling


Lecture 4 - Fundamentals of Mathematical Modelling


Lecture 5 - Fundamentals of Mathematical Modelling


Lecture 6 - Fundamentals of Mathematical Modelling


Lecture 7 - Some Example Models


Lecture 8 - Representation of Biological Networks


Lecture 9 - Lab: MATLAB Basics


Lecture 10 - Lab: MATLAB Basics


Lecture 11 - Lab: MATLAB Basics


Lecture 12 - Lab: MATLAB Basics


Lecture 13 - Introduction to Networks


Lecture 14 - Introduction to Networks


Lecture 15 - Introduction to Network Biology


Lecture 16 - Introduction to Network Biology


Lecture 17 - Introduction to Network Biology


Lecture 18 - Network Biology


Lecture 19 - Network Models


Lecture 20 - Network Models


Lecture 21 - Biological Networks


Lecture 22 - Network Perturbations


Lecture 23 - Community Detection


Lecture 24 - Network Motifs


Lecture 25 - Lab: Cytoscape


Lecture 26 - Lab: Cytoscape


Lecture 27 - Lab: Network Biology


Lecture 28 - Network Biology: Recap


Lecture 29 - Lab: Network Models and Perturbations


Lecture 30 - Lab: Network Models and Perturbations


Lecture 31 - Reconstruction of Gene Regulatory Networks


Lecture 32 - Reconstruction of Protein Networks


Lecture 33 - Reconstruction of Signalling Networks


Lecture 34 - Reconstruction of Signalling Networks


Lecture 35 - Introduction to Dynamic Modelling


Lecture 36 - Introduction to Dynamic Modelling


Lecture 37 - Introduction to Dynamic Modelling


Lecture 38 - Lab: Solving ODEs in MATLAB


Lecture 39 - Lab: Example Biological Model


Lecture 40 - Parameter Estimation


Lecture 41 - Parameter Estimation


Lecture 42 - Parameter Estimation


Lecture 43 - Methods for Parameter Estimation


Lecture 44 - Direct Search Methods


Lecture 45 - Genetic Algorithms


Lecture 46 - Genetic Algorithms


Lecture 47 - Other Evolutionary Algorithms


Lecture 48 - PyGMO


Lecture 49 - Dynamic Modelling Recap


Lecture 50 - Lab: Parameter Estimation


Lecture 51 - Guest Lecture: Modelling in Drug Development


Lecture 52 - Guest Lecture: Modelling in Drug Development


Lecture 53 - Guest Lecture: Quantitative Systems Pharmacology


Lecture 54 - Guest Lecture: Quantitative Systems Pharmacology


Lecture 55 - Guest Lecture: Quantitative Systems Pharmacology


Lecture 56 - Constraint-based Modelling of Metabolic Networks


Lecture 57 - Flux Balance Analysis


Lecture 58 - Flux Balance Analysis


Lecture 59 - Flux Balance Analysis


Lecture 60 - Other Constraint-Based Approaches


Lecture 61 - Other Constraint-Based Approaches


Lecture 62 - Lab: FBA using MATLAB


Lecture 63 - Perturbations to Metabolic Networks: Deletions


Lecture 64 - Lab: COBRA Toolbox


Lecture 65 - Understanding FBA


Lecture 66 - Understanding FBA


Lecture 67 - Perturbations to Metabolic Networks: Over-expression


Lecture 68 - Perturbations to Metabolic Networks: Synthetic Lethals


Lecture 69 - Perturbations to Metabolic Networks: Synthetic Lethals


Lecture 70 - Constraint-based Modelling of Metabolic Networks


Lecture 71 - Lab: Gene Deletions


Lecture 72 - Integrating Regulatory Information into Constraint-Based Models


Lecture 73 - Elementary Modes


Lecture 74 - Elementary Modes


Lecture 75 - Constraint-based Modelling of Metabolic Networks: Applications


Lecture 76 - Constraint-based Modelling of Metabolic Networks: Applications


Lecture 77 - Constraint-based Modelling of Metabolic Networks: Applications


Lecture 78 - Lab: Gene Deletions


Lecture 79 - Constraint-based Modelling of Metabolic Networks: Recap


Lecture 80 - Constraint-based Modelling of Metabolic Networks: Recap


Lecture 81 - Constraint-based Modelling of Metabolic Networks: Recap


Lecture 82 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry


Lecture 83 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry


Lecture 84 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry


Lecture 85 - Lab: $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry


Lecture 86 - Modelling Gene Regulatory Networks


Lecture 87 - Modelling Gene Regulatory Networks


Lecture 88 - Modelling Gene Regulatory Networks


Lecture 89 - Lab: Modelling Gene Regulatory Networks


Lecture 90 - Lab: Modelling Gene Regulatory Networks


Lecture 91 - Computational Modelling of Host-Pathogen Interactions


Lecture 92 - Computational Modelling of Host-Pathogen Interactions


Lecture 93 - Robustness in Biological Systems


Lecture 94 - Robustness in Biological Systems: Mechanisms


Lecture 95 - Robustness in Biological Systems: Organising Principles


Lecture 96 - Robustness in Biological Systems: Trade-offs


Lecture 97 - Obustness and Evolvability


Lecture 98 - obustness and Evolvability


Lecture 99 - Introduction to Synthetic Biology


Lecture 100 - Advanced Topics


Lecture 101 - Advanced Topics


Lecture 102 - Advanced Topics


Lecture 103 - Course Recap