NOC:Chemical and Biological Thermodynamics - Principles to Applications


Lecture 1 - Fundamentals of Chemical thermodynamics


Lecture 2 - Work


Lecture 3 - Tutorial-1


Lecture 4 - First Law of Thermodynamics


Lecture 5 - Tutorial-2


Lecture 6 - Adiabatic processes


Lecture 7 - Entropy


Lecture 8 - Entropy and Second Law: Basics


Lecture 9 - Entropy and Second Law: Applications


Lecture 10 - Third Law of Thermodynamics


Lecture 11 - Discussion on Helmholtz energy


Lecture 12 - Discussion on Gibbs Energy


Lecture 13 - Maxwell relations, Properties of Gibbs energy


Lecture 14 - Further discussion on properties of Gibbs energy


Lecture 15 - Fugacity


Lecture 16 - Tutorial session


Lecture 17 - Tutorial session


Lecture 18 - Chemical potential of a substance in mixture


Lecture 19 - Chemical potential of Liquids, Raoult’s Law, Henry’s Law


Lecture 20 - Thermodynamics of mixing, Excess functions


Lecture 21 - Partial molar volume


Lecture 22 - Activities (Accounting for deviations from Ideal behaviour)


Lecture 23 - Tutorial on thermodynamics of mixing and deviations from ideality


Lecture 24 - Further discussion on relation between C p and C v


Lecture 25 - Chemical Equilibrium


Lecture 26 - Perfect gas equilibria


Lecture 27 - Equilibrium constant


Lecture 28 - Effect of pressure on equilibrium constant and equilibrium composition


Lecture 29 - Effect of temperature on equilibria


Lecture 30 - Biological standard states and pH


Lecture 31 - Tutorial 1 - Equilibrium constant


Lecture 32 - Tutorial 2 - Equilibrium constant


Lecture 33 - Acids and bases and Equilibrium concepts


Lecture 34 - pH Scale Strong and weak acids and bases


Lecture 35 - Strong and weak acids and bases


Lecture 36 - Acid-base titrations


Lecture 37 - pH curve for titration of weak acid with strong base Buffers and indicators


Lecture 38 - Thermodynamics in systems of biological interest


Lecture 39 - Calorimetry


Lecture 40 - Differential scanning calorimetry (DSC)


Lecture 41 - Further discussion on Differential Scanning Calorimetry (DSC)


Lecture 42 - Explaining Differential Scanning Calorimetric Profiles (DSC Profiles)


Lecture 43 - Applications of DSC in thermal unfolding of proteins and protein-solvent interactions


Lecture 44 - Further discussion on applications of DSC in thermal unfolding of proteins and protein-solvent interactions


Lecture 45 - Isothermal Titration calorimetry (ITC)


Lecture 46 - Further discussion on Isothermal Titration calorimetry (ITC)


Lecture 47 - ITC Experimental Design and Isothermal Titration Calorimetry (ITC) in Drug Design


Lecture 48 - Isothermal Titration Calorimetry (ITC) in Drug Design


Lecture 49 - Isothermal Titration Calorimetry (ITC) in Engineering Binding Affinity


Lecture 50 - Calorimetry in identifying partially folded states of proteins (Molten Globule State)


Lecture 51 - Thermodynamic Characterization of Partially Folded States of Proteins


Lecture 52 - Quantitative Thermodynamic Characterization of Partially Folded States of Proteins


Lecture 53 - ITC in Drug-Protein Interactions


Lecture 54 - Identifying sites for Drug-Protein Interactions by ITC


Lecture 55 - Identifying sites for Drug-Protein Interactions, DSC of Protein-Ligand Complexes. Enthalpy-Entropy Compensation


Lecture 56 - Estimation of Binding Constants in Strong to Ultratight Protein-Ligand, Interactions Using Differential Scanning Calorimetry


Lecture 57 - Continuation of discussion on... Estimation of Binding Constants in Strong to UltratightProtein-Ligand Interactions Using Differential Scanning Calorimetry


Lecture 58 - Thermal unfolding of protein by non-calorimetric methods, Addressing thermodynamics of the process


Lecture 59 - Titration Calorimetry as a tool to determine thermodynamic and Kinetic parameters of enzymes


Lecture 60 - Summary of the course