NOC:Organic Chemistry in Biology and Drug Development


Lecture 1 - A brief introduction to Molecules of Life: Structure of Amino acids and their various charged forms


Lecture 2 - Biological Macromolecules and Small molecules: Importance and functions


Lecture 3 - Amino Acids: The building block of proteins


Lecture 4 - Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction


Lecture 5 - Method of determination of Amino acid sequence: primary structure of polypeptide/protein


Lecture 6 - Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods


Lecture 7 - Peptide synthesis: Protecting groups for amine and carboxyl functionality


Lecture 8 - Peptide synthesis (Continued...) Protection, coupling and deprotection method


Lecture 9 - Recent development of coupling agents; Merrifield’s method of solid phase peptide synthesis


Lecture 10 - Hierarchial structure of proteins: Secondary, tertiary and quaternary structure


Lecture 11 - Ramachandran plot and protein purification techniques


Lecture 12 - Protein purification techniques (Continued...)


Lecture 13 - Introduction to Enzymes and its kinetics


Lecture 14 - Enzyme catalysed reactions and introduction to catalytic activity of proteases


Lecture 15 - Enzyme Kinetics (Continued...)


Lecture 16 - Concept of Enzyme Inhibition


Lecture 17 - Concept of Enzyme Inhibition (Continued...)


Lecture 18 - Problems on Enzyme Kinetics and Enzyme Inhibition


Lecture 19 - Synthetic Biology


Lecture 20 - Synthetic Biology (Continued...)


Lecture 21 - Synthetic Biology (Continued...)


Lecture 22 - Nucleic Acid


Lecture 23 - Nucleic Acid (Continued...)


Lecture 24 - DNA sequencing method


Lecture 25 - DNA sequencing method (Continued...)


Lecture 26 - DNA sequencing method (Continued...)


Lecture 27 - Synthesis of oligonucleotide


Lecture 28 - Central dogma: DNA replication, transcription and translation


Lecture 29 - Central dogma: DNA replication, transcription and translation (Continued...)


Lecture 30 - Central dogma: DNA replication, transcription and translation (Continued...)


Lecture 31 - Central dogma: DNA replication, transcription and translation (Continued...)


Lecture 32 - Central dogma: DNA replication, transcription and translation (Continued...)


Lecture 33 - Molecular Biology


Lecture 34 - Molecular Biology (Continued...)


Lecture 35 - Chemistry of cofactors/coenzymes


Lecture 36 - Chemistry of cofactors/coenzymes (Continued...)


Lecture 37 - Chemistry of cofactors/coenzymes (Continued...)


Lecture 38 - Chemistry of cofactors/coenzymes (Continued...)


Lecture 39 - Chemistry of cofactors/coenzymes (Continued...)


Lecture 40 - Chemistry of cofactors/coenzymes (Continued...)


Lecture 41 - Introduction to Drug Discovery Process


Lecture 42 - Fundamental Principles of Drug Development Process


Lecture 43 - Combinatorial chemistry


Lecture 44 - Neurotransmitters


Lecture 45 - Catechol amine based and GABA neurotransmitters


Lecture 46 - Hypertension: humoral mechanism and renin/angiotensin system


Lecture 47 - Inhibitor design of angiotensin converting enzyme


Lecture 48 - Antimicrobial drugs


Lecture 49 - Chemistry of penicillins


Lecture 50 - Resistance to beta-lactam antibiotics


Lecture 51 - Mechanistic studies of beta-lactamase


Lecture 52 - Non beta-lactam antibiotics


Lecture 53 - Mechanistic enzymology of Isopenicillin N synthase


Lecture 54 - Polyketide Biosynthesis


Lecture 55 - Biosynthesis of macrolide polyketides and introduction to virus


Lecture 56 - Anti-viral drugs


Lecture 57 - Cancer and Chemotherapy


Lecture 58 - Anti-cancer drugs (Continued...)


Lecture 59 - Aromatase inhibition and Anti-ulcer drugs


Lecture 60 - Cholesterol lowering agents


Lecture 61 - Cholesterol Biosynthesis


Lecture 62 - Pharmakinetics and pharmadynamics


Lecture 63 - QSAR principles