NOC:Principles and Applications of NMR Spectroscopy


Lecture 1 - Introduction to NMR spectroscopy


Lecture 2 - The alignment of nuclear spins in presence of magnetic field


Lecture 3 - Introduction to rotating frame


Lecture 4 - Free induction decay and Fourier transformation of FID


Lecture 5 - NMR Hardware


Lecture 6 - The concept of chemical shift


Lecture 7 - Factors that affect chemical shifts


Lecture 8 - Chemical shift referencing


Lecture 9 - J-coupling


Lecture 10 - Recap of basics


Lecture 11 - Introduction to general one dimensional NMR experiment


Lecture 12 - Practical aspects of recording a 1D NMR experiment - I


Lecture 13 - Practical aspects of recording a 1D NMR experiment - II


Lecture 14 - Practical aspects of recording a 1D NMR experiment - III


Lecture 15 - NMR Data processing


Lecture 16 - Basic aspects of 1D proton NMR analysis


Lecture 17 - Analysis of an example 1D proton spectrum


Lecture 18 - Analysis of 1D 1H NMR spectra of molecules - I


Lecture 19 - Analysis of 1D 1H NMR spectra of molecules - II


Lecture 20 - 1D 13C NMR


Lecture 21 - Why do we need 2D NMR


Lecture 22 - A qualitative explanation of how 2D NMR experiment works


Lecture 23 - Principles of 2D COSY and Total correlation spectroscopy (2D TOCSY)


Lecture 24 - 2D NOE-spectroscopy


Lecture 25 - 2D NOESY and 2D ROESY


Lecture 26 - What is heteronuclear correlation NMR spectroscopy


Lecture 27 - Sensitivity enhancement of heternuclei via polarization transfer


Lecture 28 - Heteronucler multiple quantum NMR spectroscopy (2D HMQC) and Heteronuclear single quantum NMR spectroscopy (2D HSQC)


Lecture 29 - Practical aspects of recording and processing 2D HMQC or HSQC


Lecture 30 - HMBC and its utility


Lecture 31 - 2D HSQC TOCSY and its analysis with examples


Lecture 32 - Structure determination of molecules by NMR


Lecture 33 - Structure determination of peptides - I


Lecture 34 - Structure determination of peptides - II


Lecture 35 - Structure determination of peptides - III


Lecture 36 - Chemical exchange


Lecture 37 - Hydrogen or deuterium exchange


Lecture 38 - Diffusion ordered spectroscopy DOSY I


Lecture 39 - DOSY II


Lecture 40 - STD NMR for drug target interactions